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Those preliminary findings were later corroborated by several studies by us or other researchers that showed that: (a) Single and 24hour TNF and IL6 plasma levels are elevated in adults and children with sleep apnea independently of obesity (103, 118,154-158) (Figure 10) (b) body mass index (BMI) positively correlates with both TNF and IL6 levels, suggesting that these two cytokines may play a role in daytime sleepiness experienced by obese individuals in the absence of sleep apnea (25) (c) daytime levels of IL6 and TNF are elevated in healthy humans experiencing somnolence and fatigue as a result of total sleep deprivation (137) or even after a modest sleep loss by restricting sleep to 6 hours a night per week (76,159) and (d) a midafternoon nap following a night of total sleep deprivation is beneficial for both the suppression of IL6 secretion and for the improvement of alertness (83)

however, after pretreatment with epigenetic drugs such as HDACi, tumor cells express PD-L1, potentially transforming the tumor into an ICI-sensitive hot one